Kumar, md, professor of medicine, mayo clinic cancer center, and panel chair of the nccn guidelines for mm, who described mm. Patients had received a mean of three prior treatment lines range, 111. Myeloma acronyms and abbreviations ig immunoglobulin im intramuscular shot or infection into the muscle iss international staging system iv intravenous injection into the vein intravenous injection into the vein. Although multiple myeloma affects the bones, it begins in plasma cells. Some early cancers may have signs and symptoms that can be noticed, but that is not always the case.
Your doctor will examine you and ask about your symptoms, medical history and overall health. Myeloma often damages the bone and is usually called multiple myeloma because. How dcep chemotherapy is given and possible side effects. Have you wondered which of your laboratory test results to track or how best to track them. Myeloma begins when healthy plasma cells in the bone marrow change and grow out of control. Multiple myeloma mm is a cancer of postgerminal center plasma cells which remains a challenging disease with frequent relapses. Multiple myeloma is a rare type of cancer that initially has few or no symptoms. It is a highly manageable disease that has seen rapid medical advancements in the past few years. These properties render dcep a useful regimen for the debulking and mobilization phase of highdose programs for multiple myeloma.
In greek, the language of most medical terms, myelo refers to the bloodproducing cells in the bone marrow, and oma refers to a tumor or mass. Dadacaridou m1, papanicolaou x, maltesas d, megalakaki c, patos p, panteli k, repousis p, mitsoulimentzikof c. Multiple myeloma is a cancer of plasma cell, a type of white blood cell which produces antibodies to fight against infection in multiple myeloma, overcrowding of cancer cells causes production of abnormal proteins instead of helpful antibodies. A cancerous or malignant plasma cell is called a myeloma cell. Multiple myeloma remains incurable despite the use of novel agents. In myeloma, the cells grow too much, crowding out normal cells in the bone marrow that make red blood cells, platelets, and other white blood cells. Each cycle of dcep consisted of cyclophosphamide 400 mgm2 daily. Ensure youre boardexam ready with acps board prep course recordingsa multimedia, selfstudy program that delivers multiple study tools. Dexamethasone, cyclophosphamide, etoposide, and cisplatin dcep is one of the salvage options, but there has been a lack of data on salvage dcep in patients with previous exposure to novel agents. Multiple myeloma multiple myeloma is a cancer of the plasma cellsa type of white blood cell. It is for personal use only and cannot be modified. Myeloma is a cancer of the plasma cells in the bone marrow, the spongy tissue inside of bones. Treatment options for relapsed and refractory multiple myeloma. Or how to improve your multiple myeloma survival rate.
Dexamethasone, cyclophosphamide, etoposide and cisplatin dcep for relapsed or refractory multiple myeloma patients. The aim of this study was to evaluate the efficacy of dcep in mobilizing pbsc and to define its toxicity. The major features of myeloma result from the abnormal accumulation of myeloma cells within the bone marrow, causing. Each year in the united states, about 20,000 people learn they have this disease. Learn from experts about clinical trials and the multitude of treatment options. Myeloma is a cancer of plasma cells, a type of white blood cell wbc in the bone marrow that is responsible for making immunoglobulins. Multiple myeloma is a type of blood cancer that affects the bone marrow, the bodys bloodforming system. Dexamethasone, cyclophosphamide, etoposide and cisplatin dcep. Keeping track of your lab results north texas myeloma. Dexamethasone, cyclophosphamide, etoposide and cisplatin. I have the impression that dcep typically is used as a bridging therapy.
This causes them to interfere with the production of normal blood cells. Multiple myeloma early detection, diagnosis, and staging. If symptoms suggest that a person might have multiple myeloma, more tests are done. Multiple myeloma is a cancer of the bone marrow plasma cells. At the gene expression level, mgus cannot be distinguished from myeloma, although plasma cells of both mgus and myeloma can be clearly. Dexamethasone, cyclophosphamide, etoposide, and cisplatin dcep is. Multiple myeloma early detection, diagnosis, and staging 1. Criteria for mgus, asymptomatic myeloma and symptomatic myeloma from the practical point of view, the key question is whether the patient needs treatment. Multiple myeloma multiple myeloma chemotherapy free. Dcep an alternative to standard regimen in myeloma. The malignant plasma cells, or myeloma cells, accumulate in the bone marrow. Plasma cells make antibodies against infectious agents such as viruses and bacteria. Treatment options for relapsed or refractory multiple myeloma.
Multiple myeloma treatment regimens part 1 of 9 clinical trials. In a population of patients with recurrentrefractory multiple myeloma, this. Dcep is the acronym for a chemotherapy regimen used in the treatment of multiple myeloma d dexamethasone c cyclophosphamide cytoxan e etoposide vepesid p cisplatin platinol chemotherapy is often given as a combination of drugs. Sorry to hear that your transplant didnt have that much of an effect on your multiple myeloma. The nccn recommends cancer patient participation in clinical trials as the gold standard for treatment.
Request pdf dcep for relapsed or refractory multiple myeloma after therapy with novel agents multiple myeloma remains incurable despite the use of novel. Multiple myeloma free download as powerpoint presentation. The information in this document does not replace a medical consultation. Developed by our own dennis mcclure, these templates will help you organize and record your test results that you should track as. Georgetown university codivision chief, director of research multiple myeloma division john theurer cancer center hackensack university medical center. A comparison of salvage infusional chemotherapy regimens for. Multiple myeloma mm is the second most common hematological malignancy, with an incidence of 6100 000 in europe. Dcep for relapsed or refractory multiple myeloma after therapy with. Myeloma is a cancer of the plasma cells in the bone marrow.
Tests to find multiple myeloma american cancer society. Anyone else been diagnosed with this that i can chat with. I dont have any experience with the dcep regimen, but i do have a one question and one observation that may be helpful. Dcep as a bridge to ongoing therapies for advanced. Cancer therapy selection, dosing, administration, and the management of related adverse events can be a complex process that should. The complete blood count cbc is a test that measures the levels of red cells, white cells, and platelets in the blood. Dcep, d exam eth ason ecy clo phos pham ideeto pos idecis plat in.
If youre suffering from myeloma, or know someone who is, join this support group. Emergency physicians should suspect multiple myeloma based on pathologic fractures, back or bone pain at rest, normocytic anemia, and renal failure in an older patient. I have provided some updates including a new section on early. Dcep as a bridge to ongoing therapies for advanced relapsed andor refractory multiple myeloma. The predominant change to the nccn guidelines for multiple myeloma mm is the grouping of treatment regimens according to preferred, other, and useful in certain circumstances, according to shaji k. The changing paradigm patient case and question a 65yearold violinist is diagnosed with myeloma and receives revlimid, velcade, and dexamethasone rvd followed by highdose melphalan and stem cell transplantation and revlimid maintenance.
Dcep as a bridge to ongoing therapies for advanced relapsed and. In 2015, an estimated 28,850 new cases of multiple myeloma were. Diagnostic and clinical implications ronald walker, bart barlogie, jeffrey haessler, guido tricot, elias anaissie, john d. If there are too many myeloma cells in the bone marrow, some of these blood cell levels can be low. Its diagnosed and treated differently from multiple myeloma. For some patients, thalidomide was added to the dcep regimen, and. Myeloma is synonymous with multiple myeloma and plasma cell myeloma.
Treatment options for relapsed or refractory multiple. Initial studies 3 years ago showed 55% plasma cells in the bone marrow, hyperdiploidy, igg. Pdf dcep is an effective regimen for peripheral blood stem cell. Relapsed myeloma is defined as disease in a myeloma patient who has previously been treated and has evidence of pd as defined here before, and who at the time of relapse does not meet the criteria for relapsed and refractory or primary refractory myeloma. Stem cell collection between cycles 3, 4 after gcsf vad bortdex second asct or reducedintensity conditioning allogeneic transplantation if dcep is an effective bridge to autologous stem cell transplant asct or novel agents in patients with relapsed refractory multiple myeloma. Request pdf dcep for relapsed or refractory multiple myeloma after therapy with novel agents multiple myeloma remains incurable despite the use of novel agents. In this disease, the plasma cells a type of white blood cell become abnormal and multiply rapidly.
Cancer therapy selection, dosing, administration, and the management of related adverse events can. Each cycle of dcep consisted of cyclophosphamide 400 mgm2daily. Multiple myeloma 2015 update why do people beat the. Genomic instability, a hallmark of multiple myeloma, is already present at the stage of monoclonal gammopathy of undetermined significance mgus, 1012 but it is not clear whether mgus represents a prerequisite precursor stage for all cases of myeloma. Dcep dexamethasone, cyclophosphamide, etoposide, and cisplatin has proved to be an effective salvage therapy for refractoryrelapsed mm patients. I was just last week diagnosed with multiple myeloma after a bone marrow biopsy. Low numbers of these cells may also be found in the bloodstream whenever the immune system is triggered. Little is known, however, about its potential as mobilizing therapy. These properties render dcep a useful regimen for the debulking and mobilization phase of highdose pro. Treatment of multiple myeloma blood american society. Pdf current treatment strategies for multiple myeloma. Myeloma is a cancer of plasma cells in the bone marrow. For that reason, the international myeloma working group 2003 defined patient groups to identify those with mgus, asymptomatic myeloma and symptomatic myeloma who require treatment. Myeloma, also called multiple myeloma, is a cancer of the plasma cells.
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